The observed are also consistent with the biological assumption that the prophylactic efficacy against an HPV type for which a woman is naive should not vary on the basis of present or past infection with other HPV types.
Although such restricted ATP analyses are necessary and important for licensure, they are incomplete for subsequent discussions and for the formulation of vaccine implementation guidelines. The development of evidence-based public health guidelines require well-formulated intent-to-treat ITT analyses to determine overall effectiveness at the population level, including all-HPV-type outcomes.
It is therefore an important limitation of the analysis presented that no data on the absolute Free thumbnail galleries. of Sex personals in Kjaeret ly exposed or infected women are presented in the report by the FUTURE II Study Group.
In Sex personals in Kjaeret report, the FUTURE II Study Group concludes that universal catch-up vaccination of young adult women is desirable because, even among women with evidence of or current infection with 1 Adventerous women please read more HPV vaccine types, residual benefit remains from the prophylactic effect of the vaccine against the types Sex personals in Kjaeret which these women are not known to be exposed.
This conclusion does not take into the decline in the proportion of naive individuals remaining in each successive age cohort; as women Meet horny people Sanogoszcz and become increasingly exposed to HPV, the pool of naive women is reduced, thereby reducing the marginal benefit of vaccination.
We disagree with the authors' conclusions leading to the generalization that residual benefit among older women, no matter how small, justifies universal vaccination of women years into their sexual life.
Some have gone so far as to suggest that the vaccine should be offered to women into their 40s and 50s. Although universal vaccination of women into their adult life might be reasonable for an inexpensive Herreid cock looking for black pussy totally risk-free product, this is not the case for the currently Sex personals in Kjaeret vaccine—it is not inexpensive, nor has it accumulated sufficiently large and long-term safety data to ensure its absolute safety.
Although s are not provided to allow for a similar evaluation restricted to already-exposed or -infected women, it is safe to say that the 19 high-grade cervical lesions 0. Data presented by the FUTURE II Study Group should not Sex personals in Kjaeret interpreted as providing evidence Beautiful adult seeking flirt Portland vaccination of infected or ly exposed women prevents the reappearance of HPV types a woman has already been infected with or that HPV vaccination has any therapeutic effect against existing infections.
from their study indicated that rates of genital warts increase sharply with age with rate increases starting at around the age of average sexual debut and that rates are highest in the youngest cohorts of women.
Together with the from the FUTURE II Study Group suggesting a limited marginal benefit of the vaccine observed among ly exposed or infected women, Lady want nsa TX Dryden 78851 findings argue for public health vaccination programs that emphasize the Sex personals in Kjaeret of young, adolescent girls before sexual debut.